Objective To explore the curative effect of fixed orthodontic treatment in the treatment of anterior malocclusion during dental transitional period. Methods From January 2017 to January 2021, 57 patients with anterior malocclusion during dental transitional period admitted to our hospital were selected as the research objects. All patients were treated with straight wire appliance. The overall correction effect, oral function, occlusal relationship of tooth function and facial aesthetics were recorded. Results All patients were followed up for 1-2 years without recurrence. The oral function and dental function of children after orthodontic treatment were better than those before orthodontic treatment (P