Objective To discuss the value of case based study method in clinical teaching of thyroid plastic surgery suture. Methods From January 2021 to December 2022, 90 interns from thyroid surgery department of Xuzhou Cancer Hospital were selected as the research objects, and they were divided into reference group and experimental group by random number table method, with 45 interns in each group. The reference group was given the traditional clinical teaching method, and the experimental group was given the case based study method on the basis of the reference group. The self-directed learning ability, comprehensive ability and assessment results of the two groups were compared. Results The scores of learning behavior, learning consciousness, learning strategies, interpersonal skills and learning evaluation in the experimental group were higher than those in the reference group (P