Objective To investigate the clinical effect of Liushen pills in the treatment of acne vulgaris. Methods A total of 136 patients with acne vulgaris admitted to the No.2 Hospital of Baoding, Hebei Province from January 2022 to April 2023 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 68 patients in each group. The control group was treated with conventional western medicine, and the observation group was treated with Liushen pills on the basis of the control group. The skin physiological status, rash and TCM symptom scores of the two groups were compared. Results After treatment, the skin water content of the observation group was higher than that of the control group, and the skin oil content was lower than that of the control group (P