Objective To analyze the clinical efficacy of intensive pulsed light combined with tacrolimus ointment in the treatment of rosacea. Methods A total of 105 patients with rosacea who were treated in our hospital from October 2021 to December 2022 were selected as the research objects. According to the random number table method, they were divided into group A, group B and group C, with 35 patients in each group. Group A was treated with intensive pulsed light, group B was treated with tacrolimus ointment, and group C was treated with intensive pulsed light combined with tacrolimus ointment. The clinical efficacy, skin barrier function and adverse reactions of the three groups were compared. Results The total effective rate of treatment in group C was higher than that in group A and group B (P