Objective To explore the clinical effect of compound acid in the treatment of acne. Methods A total of 56 patients with acne admitted to our hospital from June 2020 to June 2022 were selected as the research objects. All patients were treated with compound acid. The clinical efficacy at 4, 8 and 12 weeks after treatment and skin image indexes were observed. Results The total effective rate of 56 patients after 8 weeks of treatment was higher than that after 2 and 4 weeks of treatment, and the difference was statistically significant (P