Objective To explore the application effect of traditional Chinese medicine in the treatment of patients with skin eczema. Methods Forty patients with skin eczema admitted to Xinglong Community Health Service Center of Changzhou District of Wuzhou City from April 2022 to April 2023 were selected as the research objects. They were divided into control group and observation group by random number table method, with 20 patients in each group. The control group was treated with conventional western medicine, and the observation group was treated with traditional Chinese medicine. The clinical efficacy and quality of life of the two groups were compared. Results The total effective rate of treatment in the observation group was 95.00%, which was higher than 70.00% in the control group, and the difference was statistically significant (P