Objective To explore the application effect of standardized pain management mode in oral and maxillofacial surgery nursing. Methods A total of 80 patients who were treated in the Department of Oral and Maxillofacial Surgery of the First People's Hospital of Kashgar Region from January to December 2022 were randomly divided into the reference group and the study group, with 40 patients in each group. The reference group was given routine nursing, and the study group was given standardized pain management mode. The nursing effect, pain, quality of life, depression and satisfaction were compared between the two groups. Results The total effective rate of nursing in the study group was 97.50%, which was higher than 80.00% in the reference group, the difference was statistically significant (P