Objective To explore the application effect of perioperative high quality nursing in patients with scar after burn. Methods A total of 68 patients with scar after burn who underwent plastic surgery in our hospital from April 2021 to March 2023 were selected as the research objects. They were divided into control group and experimental group by random number table method, with 34 patients in each group. The control group was given traditional nursing, and the experimental group was given perioperative high quality nursing. The comfort, hospitalization time, ambulation time and psychological status of the two groups were compared. Results The comfort score of the experimental group was higher than that of the control group, and the hospitalization time and ambulation time were shorter than those of the control group (P