Objective To explore the effect of comprehensive nursing in children with psoriasis. Methods A total of 40 children with psoriasis admitted to our hospital from March 2021 to March 2023 were randomly divided into control group and observation group, with 20 children in each group. The control group was given routine nursing, and the observation group was given comprehensive nursing. The nursing effect, negative emotion and nursing satisfaction of the two groups were compared. Results The total effective rate of nursing in the observation group was higher than that in the control group (P