Objective To explore the application effect of clinical nursing pathway in patients with asymmetric double eyelid plastic surgery. Methods A total of 74 patients who underwent asymmetric double eyelid plastic repair in our hospital from January 2021 to January 2023 were randomly divided into control group (n=35) and study group (n=39). The control group received routine nursing, and the study group received clinical nursing pathway. The incidence of postoperative complications, nursing satisfaction and inflammatory factor levels were compared between the two groups. Results The incidence of infection, bleeding, swelling and other complications in the study group was lower than that in the control group, the difference was statistically significant (P