Objective To explore the application effect of high quality nursing in the nursing of children with eczema. Methods A total of 38 children with eczema admitted to our hospital from April 2021 to April 2023 were selected as the research objects. They were divided into control group and observation group by random number table method, with 19 children in each group. The control group was given routine nursing, and the observation group was given high quality nursing on the basis of the control group. The treatment effect, symptom relief time, eczema severity and nursing satisfaction were compared between the two groups. Results The total effective rate of the observation group was 94.74%, which was higher than 68.42% in the control group, the difference was statistically significant (P