In the current medical and aesthetic research projects, although there are some systems and processes, there are still some difficulties in the implementation process. In this regard, this paper makes an in-depth discussion on the current situation of medical and aesthetic research projects. It is suggested to further improve the existing novelty search work by strengthening the construction of medical and aesthetic novelty search system, strengthening the construction of medical and aesthetic novelty search team, optimizing the process of novelty search, and communicating with clients. The purpose is to provide a feasible reference for improving the quality and efficiency of medical and aesthetic research projects, so as to lay a solid foundation for the successful implementation of medical and aesthetic research projects.