Objective To explore the effect of focus orientation model on self-image of breast cancer patients after mastectomy. Methods A total of 84 patients with breast cancer admitted to our hospital from June 2019 to June 2022 were selected as the research objects. They were divided into control group and experimental group by random number table method, with 42 patients in each group. The control group received routine postoperative intervention, and the experimental group received focused orientation mode on the basis of the control group. The self-image and perceived stress of the two groups were compared. Results After the intervention, the BIBCQ scores and total scores of the two groups were lower than those before the intervention, and the experimental group was lower than the control group (P