In order to analyze the clinical effect of CAD/CAM chair-side immediate restoration technology in the upper restoration of single implant denture, this study selected 20 patients ( 21 prostheses ) who visited the Department of Stomatology of Mianyang Hospital of Traditional Chinese Medicine from October 2019 to December 2020 and completed implant restoration. Three to six months after implant surgery and one month after soft tissue plasty before repair, the screw-retained one-piece crown was made by using Ti-base multienergy abutment and high-precision CAD/CAM technology of CEREC chairside all-ceramic restoration system. Two years later, the implant effect, the level of soft tissue around the implant, the level of prosthesis structure and the satisfaction of patients were evaluated. The X-ray films of 21 implants showed that the implant was closely combined with the bone, and there was no obvious absorption of the alveolar bone in the neck. The buccal and lingual attached gingiva of 21 prostheses were ≥2 mm. Among them, 2 cases showed plaque accumulation in the neck of the teeth. In 2 cases, plaque was found on the surface of dental neck prosthesis by probe. Among the 4 prostheses with plaque detected in the department, 3 prostheses had slight swelling around the gingival margin and linear bleeding in the gingival sulcus. The probing depth of all patients was less than 4 mm. The crown shape, contour, color, texture and transparency were rated as grade 2. Occlusal examination showed that there was no high point in the middle occlusion and no interference in functional movement, and there were depressions in the resin fillings at the screw holes of 2 restorations. No porcelain collapse, shedding, fracture, etc. were found; subjective feelings of patients: 21 prostheses had no obvious discomfort when used, and patients were generally satisfied with the appearance and chewing ability of the prostheses. Using CAD/ CAM chair-side immediate restoration technology for upper implant restoration, the shape and color of the restoration can meet the requirements of doctors and patients. However, due to the limited quality of existing research and the lack of longterm clinical results data for 5 years or more, the current scientific evidence is limited, and its long-term effect needs further research and observation.