Objective To explore the clinical effect of Xiaoyao powder combined with Qibai powder in the treatment of female chloasma with liver depression and qi stagnation. Methods From January 2021 to January 2023, 60 female patients with chloasma of liver depression and qi stagnation type admitted to our hospital were randomly divided into control group and observation group, with 30 patients in each group. The control group was treated with Xiaoyao powder, and the observation group was treated with Qibai powder on the basis of the control group. The improvement of TCM symptom score, skin lesion area, color spot color, serum MDA, LPO, SOD levels and the incidence of complications were compared between the two groups. Results After treatment, the scores of TCM symptoms, skin lesion area and spot color in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, the differences were statistically significant (P <0.05). After treatment, the levels of serum MDA and LPO in the two groups were lower than those before treatment, and the level of serum SOD was higher than that before treatment, and the levels of MDA and LPO in the observation group were lower than those in the control group, and the level of SOD was higher than that in the control group, the differences were statistically significant (P <0.05). The incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion Modified Xiaoyao powder combined with Qibai powder has a definite clinical effect in the treatment of female chloasma of liver depression and qi stagnation type, which can effectively improve the skin lesion area and color of the patients, regulate the serum level, and reduce the occurrence rate of complications.