Objective To analyze the effect of non-invasive skin stapler on incision healing after calcaneal fracture surgery. Methods A total of 50 patients who underwent calcaneal fracture surgery were selected from January to December 2022 in Shilou Town Central Hospital of Shanxian, and they were divided into observation group and control group by random number table method, with 25 patients in each group. The control group underwent calcaneal fracture internal fixation, and normal incision suture was performed around the ankle joint after surgery. The observation group underwent calcaneal fracture internal fixation+noninvasive skin stapler suture. The surgical indicators, postoperative adverse reactions and patient satisfaction were compared between the two groups. Results The operation time of the observation group was shorter than that of the control group, and the difference was statistically significant (P <0.05). The postoperative incision healing time of the observation group was shorter than that of the control group, and the difference was statistically significant (P <0.05). The incision aesthetics of the observation group was better than that of the control group at 1, 2 and 3 days after operation, and the difference was statistically significant (P<0.05). The incidence of postoperative adverse reactions in the observation group was 0, which was lower than 20.00% in the control group, and the difference was statistically significant (P <0.05). The satisfaction of patients in the observation group was 96.00%, which was higher than 88.00% in the control group, and the difference was statistically significant (P <0.05). Conclusion The application of non-invasive non-invasive skin stapler can reduce the surgical trauma in patients with calcaneal fracture surgery, shorten the wound healing time, improve the appearance of the wound, and have fewer adverse reactions.