Objective To observe the curative effect of lattice injection of shaobei injection in the treatment of axillary osmidrosis. Methods From January 2020 to December 2021, 60 patients with axillary osmidrosis treated with Shaobei injection in the outpatient department of our hospital were selected as the research objects. They were divided into control group and observation group by random number table, with 30 patients in each group. The control group was treated with traditional injection, and the observation group was treated with lattice injection. The patients were followed up for 6 to 12 months after treatment. The clinical efficacy and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 96.67%, which was higher than 90.00% in the control group, but the difference was not statistically significant (P >0.05). The incidence of adverse reactions in the observation group was 20.00%, which was lower than 46.67% in the control group, and the difference was statistically significant (P <0.05). Conclusion Shaobei injection can effectively treat axillary osmidrosis, and lattice injection can reduce the incidence of adverse reactions after treatment and improve its application safety.