Objective To explore the effect of CICARE communication mode in patients with upper eyelid skin relaxation undergoing plastic repair surgery. Methods A total of 56 patients with upper eyelid skin relaxation who underwent plastic surgery in the Department of Plastic Surgery of our hospital from November 2022 to April 2023 were selected as the research objects. They were divided into control group and observation group by random number table method, with 28 patients in each group. The control group was given routine nursing communication mode, and the observation group was given CICARE communication mode. The psychological status, health knowledge awareness rate and nursing satisfaction of the two groups were compared. Results The SDS score and SAS score of the two groups on the day after operation were lower than those of 1 d before operation, and those of the observation group were lower than those of the control group (P <0.05). The awareness rate of health knowledge in the observation group was 82.14%, which was higher than 47.14% in the control group (P <0.05). The nursing satisfaction of the observation group was 92.86%, which was higher than 67.86% of the control group (P <0.05). Conclusion The application of CICARE communication mode in patients with upper eyelid skin relaxation undergoing plastic repair surgery is effective, which can effectively improve the psychological status of patients, improve their health knowledge awareness rate, and help improve nursing satisfaction.