Photodynamic therapy ( PDT ) is a kind of physical therapy. Its mechanism of action is to use the interaction of light, photosensitizer and oxygen to play a role in the treatment of diseases. It is gradually widely used in the clinical treatment of tumor diseases and skin diseases. The physiological process of skin wound healing is more complex and is a dynamic change. Normally, skin can maintain skin metabolism through self-renewal and differentiation, but after skin trauma, the remaining expanded pluripotent stem cells ( EPSCs ) in the skin are activated and produce more expanded cells. When EpSCs are damaged, the skin loses its self-healing function. With the clinical application of PDT, it can reconstruct the damaged skin tissue and has a positive effect on promoting the healing of skin infections and non-infectious wounds. This article reviews the role, mechanism and clinical significance of PDT in skin wound healing, in order to provide some reference for the treatment of similar skin diseases.