Objective To explore the application effect of poly-L-lactic acid combined with gold ultrasonic gun in facial rejuvenation treatment. Methods A total of 23 patients with facial skin relaxation and telangiectasia who were treated in our hospital from February to April 2023 were selected as the study subjects. All patients were treated with poly-L-lactic acid combined with gold ultrasonic gun. The severity scores of nasolabial groove and puppet pattern, overall aesthetic improvement rate, facial telangiectasia improvement rate, patient satisfaction and incidence of adverse reactions were compared before and after treatment. Results The MAS nasolabial sulcus score of 23 patients after treatment was (0.96±0.37) scores, which was better than (1.87±0.46) scores before treatment, and the difference was statistically significant (P