Objective To explore the effect of facial liposuction combined with autologous fat filling on facial contour remodeling and rejuvenation. Methods From March 2021 to April 2022, 386 patients with poor facial contour admitted to the Plastic Surgery Department of Chengdu Chengya Jingfu Aesthetic Medicine Outpatient Department Co., Ltd. were selected as the research objects. They were divided into control group and observation group by random number table method, with 193 patients in each group. The control group was treated with facial liposuction combined with sodium hyaluronate filling, and the observation group was treated with facial liposuction combined with autologous fat filling. The facial contour remodeling effect, rejuvenation effect, complications and treatment satisfaction were compared between the two groups. Results The score of facial depression in the observation group was lower than that in the control group, and the scores of thin face effect, wrinkle regression, skin tightness and facial contour were higher than those in the control group (P