Objective To explore the value of autologous fat granule transplantation in facial rejuvenation. Methods A total of 72 patients who voluntarily requested facial rejuvenation admitted to our hospital from September 2019 to September 2020 were selected as the research objects. They were divided into control group and study group by random number table method, with 36 patients in each group. The control group was treated with hyaluronic acid injection, and the study group was treated with autologous fat granule transplantation. Results The postoperative satisfaction rate of the study group was higher than that of the control group (P