Objective To investigate the effect of orthodontic treatment with micro-implant anchorage. Methods Eighty patients with orthodontic treatment admitted to our hospital from November 2020 to October 2021 were selected and included in the control group and the observation group according to different treatment methods, with 40 patients in each group. The control group was treated with metal bracket orthodontic treatment, and the observation group was treated with micro-implant anchorage. The tooth convex distance, inclination angle difference, molar displacement, gingival health status, oral health status, chewing function, clinical efficacy and adverse reactions were compared between the two groups. Results The difference of convex distance and inclination angle of teeth in the observation group was greater than that in the control group, and the displacement of molars was smaller than that in the control group, the difference was statistically significant (P