Objective To investigate the effect of combined periodontal and orthodontic treatment for periodontal disease. Methods A total of 90 patients with periodontal disease admitted to our hospital from January 2020 to December 2022 were randomly divided into observation group and control group, with 45 patients in each group. The control group was treated with simple periodontal treatment, and the observation group was treated with periodontal and orthodontic combined treatment. The periodontal health index, chewing function, dental aesthetic status, clinical efficacy and complication rate were compared between the two groups. Results After treatment, the values of BOP, AL, SBI, PD and PIL in the observation group were lower than those in the control group, the differences were statistically significant (P