Objective To investigate the effect of minimally invasive circumcision on implant loosening after oral implantation in patients with dentition defect. Methods A total of 102 patients with dentition defect admitted to our hospital from January 2021 to December 2022 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 51 patients in each group. The control group was treated with traditional flap implantation, and the observation group was treated with minimally invasive circumcision. The quality of life, implant loosening, implant stability coefficient, alveolar crest bone resorption, periodontal probing depth, gingival sulcus bleeding index, incidence of adverse reactions and pain degree were compared between the two groups. Results The scores of all dimensions of quality of life in the observation group were lower than those in the control group (P0.05 ). The implant stability coefficient of the observation group was higher than that of the control group, and the absorption of alveolar crest bone was lower than that of the control group (P