In order to explore the application effect of local flap in repairing skin and soft tissue defects of head and face after tumor resection, this study selected 50 patients with skin and soft tissue defects after tumor resection due to head and face lesions admitted to our hospital from July 1, 2021 to November 1, 2022 as the research objects. After 6 months of follow-up, the length of surgical incision, blood supply of flap and patients' satisfaction with repair were observed. The average follow-up time was (14.46±2.38) months. The results showed that the length of the surgical incision was (4.29±1.11) cm, and the average suture removal time was (5.28±0.28) days. The blood supply of 98.00% of the flaps was good, and only 1 case was tip ischemia. The satisfaction survey showed that 27 patients (54.00%) were very satisfied, 12 patients (24.00%) were relatively satisfied, 7 cases (14.00%) were acceptable, and 4 patients were lost to follow-up. Therefore, the local flap has an ideal repair effect in repairing the skin and soft tissue defects of the head and face after tumor resection.