Objective To investigate the clinical therapeutic effect of negative pressure suction and subcutaneous pruning in patients with axillary odor. Methods 100 axillary odor patients admitted to our hospital from June 2020 to August 2022 were selected as the study objects, and they were divided into the observation group and the control group by random number table method, with 50 patients in each group. In the control group, the control group were treated by small axillary incision subcutaneous pruning, and the observation group added negative pressure suction combined with curettage to compare the clinical treatment effect, the clinical indicators, the pain and adverse reactions of the two groups. Results The total effective rate of treatment in the observation group was 100.00%, higher than 80.00% in the control group (P