Objective To study the influence of lateral episiotomy subcutaneous cosmetic suture combined with comprehensive nursing intervention on postpartum incision healing. Methods From October 2022 to March 2023, 74 primiparas with lateral episiotomy admitted to our hospital were selected as the research objects. They were divided into observation group and control group by random number table method. The control group was treated with lateral episiotomy subcutaneous cosmetic suture combined with routine nursing. The observation group was treated with lateral episiotomy subcutaneous cosmetic suture combined with comprehensive nursing intervention. The incision aesthetics, total labor time, incision healing time and knot reaction were compared between the two groups. Results The scores of VSS in the observation group were lower than those in the control group (P