Objective To investigate the effect of orthodontic combined with implant restoration in the treatment of tooth defect, dentition defect with malocclusion. Methods From March 2021 to January 2023, 60 patients with tooth defect or (and) dentition defect with malocclusion were randomly divided into single restoration group (n=30) and orthodontic+ restoration group (n=30). The single restoration group was treated with dental restoration or (and) dental implant restoration, and the orthodontic+restoration group was treated with orthodontics combined with implant restoration. The clinical efficacy, dental function, oral health status and complications were compared between the two groups. Results The total effective rate of orthodontic+ restoration group was 96.67%, which was higher than 66.67% of single restoration group (P<0.05). The scores of oral cleanliness, chewing function, occlusal function and pronunciation function in the orthodontic+restoration group were higher than those in the single restoration group (P<0.05). The OHIP-14 score in the orthodnic+restoration group was lower than that in the single repair group (P>0.05). The incidence of complications after treatment in the orthodontic+restoration group was 16.67%, which was compared with 13.33% in the single repair group, the difference was not statistically significant (P>0.05). Conclusion Orthodontic treatment before restoration can effectively improve the malocclusion of patients. Combined with follow-up restoration treatment, it can solve the problem of tooth and dentition defect, effectively restore normal tooth function, improve oral health level, and do not increase the risk of complications. The clinical application is safe and reliable.