To observe the hemostatic effect of concentrated growth factor (CGF) in the removal of impacted tooth wound through opening the gingival flap. Methods From August 2021 to July 2022, 120 patients with impacted teeth were randomly divided into observation group and control group, with 60 patients in each group. The control group did not place any material on the tooth extraction wound and was treated with routine suture. The observation group was treated with CGF and suture in the extraction wound. The wound bleeding rate after 30 min of impacted tooth extraction and bleeding time were compared between the two groups. Results The bleeding rate of the observation group was 18.33%, which was lower than 46.67% of the control group, and the difference was statistically significant (P <0.05). The bleeding time of the observation group was shorter than that of the control group, and the difference was statistically significant (P <0.05). Conclusion For patients undergoing incision and flap extraction of impacted teeth, implantation of CGF and suture has better hemostatic effect than conventional suture of wounds, which can effectively shorten the bleeding time and reduce the amount of bleeding after extraction of impacted teeth.