To study the application effect of standardized operation procedures for medical cosmetology in laser cosmetology technology. Methods A total of 200 patients who underwent laser cosmetic surgery in our hospital from April to September 2022 were randomly divided into control group and observation group, with 100 patients in each group. The control group was given routine perioperative nursing, and the observation group was given standardized operation procedures for medical cosmetology. The psychological status, skin lesion status, complications and satisfaction of the two groups were compared. Results After intervention, the SAS score and SDS score of the observation group were lower than those of the control group (P <0.05). After intervention, the skin lesion color score and color uniformity score of the observation group were lower than those of the control group (P <0.05). The incidence of complications in the observation group was 7.00%, which was lower than 18.00% in the control group (P <0.05). The satisfaction rate of the observation group was 95.00%, which was higher than 81.00% of the control group (P <0.05). Conclusion The application of standardized operation procedures for medical cosmetology in laser cosmetology is effective, which can effectively reduce the anxiety and depression of patients, improve their skin lesions, prevent postoperative complications and improve patient satisfaction.