To explore the aesthetic effect of lip filling with sodium hyaluronate gel. Methods A total of 120 female beauty seekers who underwent lip filling in our hospital from January 2021 to January 2022 were selected as the research objects. According to the random number table method, they were divided into control group and experimental group, with 60 seekers in each group. The control group was filled with collagen, and the experimental group was filled with sodium hyaluronate gel. The lip peak stereo feeling, lip line clarity, lip line improvement and satisfaction were compared between the two groups. Results The improvement of lip shape, lip line clarity and lip lines in the experimental group was better than that in the control group, and the difference was statistically significant (P <0.05). The satisfaction rate of the experimental group was 88.33%, which was higher than 58.33% of the control group, and the difference was statistically significant (P <0.05). Conclusion Lip filling with sodium hyaluronate gel can effectively improve the lip shape, lip line clarity and lip lines, enhance the color saturation and gloss of the lip red area, achieve symmetrical beauty, and achieve natural and rich lip aesthetic effect.