To explore the effect of photorejuvenation technology combined with collagen dressing paste in skin cosmetology. Methods A total of 150 patients who underwent skin cosmetic treatment in our hospital from May 2020 to August 2022 were randomly divided into control group and observation group, with 75 patients in each group. The control group was treated with photorejuvenation technology, and the observation group was treated with photorejuvenation technology combined with collagen dressing paste. The clinical efficacy, mental status, recurrence and adverse reactions of the two groups were compared. Results The total effective rate of treatment in the observation group was 96.00%, which was higher than 60.00% in the control group (P <0.05). After intervention, the SAS score and SDS score of the observation group were lower than those of the control group (P <0.05). The recurrence rate of the observation group was 0, which was lower than 6.67% of the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P >0.05). Conclusion The application effect of photorejuvenation technology combined with collagen dressing paste in skin cosmetology is exact, which can improve the cosmetic effect, effectively alleviate the bad mood of patients. At the same time, this method can reduce the recurrence rate after treatment, will not increase the risk of adverse reactions, and the prognosis is ideal.