To investigate the effect of glycyrrhizin mask on the improvement of high response state of facial sensitive skin. Methods A total of 108 patients with facial sensitive skin who were treated in the dermatology clinic of Chongqing Hospital of Traditional Chinese Medicine from April to October 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 54 patients in each group. The control group was treated with hyaluronic acid repair dressing for adjuvant treatment, and the observation group was treated with glycyrrhizin mask for adjuvant treatment. The sensitivity index, clinical efficacy, non-invasive quantitative detection index of skin and comprehensive use sense were compared between the two groups. Results The sensitivity index of the two groups after treatment was lower than that before treatment, and that of the observation group was lower than that of the control group (P <0.05). The total effective rate of treatment in the observation group was 75.00%, which was higher than 37.74% in the control group (P <0.05). After treatment, TEWL in the two groups was lower than that before treatment, and the water content of stratum corneum was higher than that before treatment, while TEWL in the observation group was lower than that in the control group, and the water content of stratum corneum was higher than that in the control group (P <0.05). The scores of adhesion, absorption, moisturizing, convenience, acceptance and satisfaction of the mask in the observation group were higher than those in the control group (P <0.05). Conclusion Glycyrrhizin mask can effectively improve the high response state of skin in patients with facial sensitive skin, repair sensitive muscles, and is easy to use and easy to be accepted by patients.