To explore the role and value of personalized nursing in tooth whitening treatment. Methods Sixty patients who underwent tooth whitening treatment in our hospital from August 2022 to June 2023 were selected as the research objects. They were divided into control group and observation group by random number table method, with 30 patients in each group. The control group was given routine nursing operation, and the observation group was given personalized nursing operation. The nursing effect and satisfaction of the two groups were compared. Results The total effective rate of the observation group was 93.33%, which was higher than 73.33% of the control group (P <0.05). The satisfaction of the observation group was higher than that of the control group (P <0.05). Conclusion Personalized nursing can effectively improve the nursing effect and patient satisfaction in tooth whitening treatment, and has higher clinical application value.