To investigate the synergistic effect of luteolin extracted from platycodon grandiflorum and silver sulfadiazine in the treatment of superficial degree Ⅱ scalds, providing new theoretical basis for optimizing the treatment plan. Methods SD rat model of superficial degree Ⅱ scald was constructed and divided into five groups according to the administration : group A was the model group, group B was the sulfadiazine silver group, group C was the luteolin group, group D was the sulfadiazine silver and luteolin combination group, and group N was the normal control group. The efficacy of different administration groups was evaluated according to the wound healing rate on the 4th and 7th day of administration. The wound diameter in the scalded area of rats was measured. The pathological changes of wound skin tissue were observed by hematoxylineosin (HE) staining. The expressions of vascular endothelial growth factor (VEGF), matrix metalloproteinase 2 (MMP-2) and type I collagen (Coll-Ⅰ) in wound skin tissue of rats were detected by Western blot. The levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in rats were detected by ELISA. Results The healing rate of scald wounds in group B and group C was higher than that in group A on the 7th day (P <0.05). The healing rate of scald wounds in group D was higher than that in group A, group B and group C on the 7th day (P <0.05). The skin layer of group D was intact, the structure of stratum corneum, epidermis and dermis was normal, and the skin hair follicles and accessory structures were basically intact, the degree of recovery was better than that of group B and group C. The levels of VEGF and Coll-Ⅰ in group B and group C were higher than those in group A, and the level of MMP-2 was lower than that in group A (P <0.05). There was no significant difference in the levels of VEGF, Coll-Ⅰ and MMP-2 between group B and group C (P >0.05). The levels of VEGF and Coll-Ⅰ in group D were higher than those in group A, group B and group C, and the levels of MMP-2 were lower than those in group A, group B and group C (P<0.05). The levels of TNF-α in group B and group C were lower than those in group A (P<0.05). There was no significant difference in the level of TNF-α between group B and group C (P >0.05). There was no significant difference in IL-10 level among group A, group B and group C (P >0.05). The level of TNF-α in group D was lower than that in group A, group B and group C, and the level of IL- 10 was higher than that in group A, group B and group C (P <0.05). Conclusion The effect of silver sulfadiazine combined with luteolin in the treatment of superficial degree Ⅱ scalds is better than that of single drug. One of the potential mechanisms may be to down-regulate the expression of MMP-2, up-regulate the expression of VEGF, Coll-I and IL-10, and inhibit the expression of TNF-α and other factors, so as to reduce tissue inflammation, improve the skin tissue environment of scald wounds and promote healing.