To explore the effect of dexmedetomidine combined with dezocine on anesthesia in patients undergoing facial plastic surgery. Methods A total of 200 patients who underwent facial plastic surgery in our hospital from January 2021 to January 2022 were randomly divided into control group and observation group, with 100 patients in each group. The control group was given dexmedetomidine for anesthesia, and the observation group was given dexmedetomidine combined with dezocine for anesthesia. The recovery time, conscious-ness time, postoperative analgesia, sedation and adverse reactions were compared between the two groups. Results The recovery time and consciousness time of the observation group were shorter than those of the control group, and the differences were statistically sig-nificant (P <0.05). The postoperative analgesia score and sedation score of the observation group were higher than those of the control group, and the differences were statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 1.00%, which was lower than 7.00% in the control group, and the difference was statistically significant (P <0.05). Conclusion Dexmedetomidine combined with dezocine for anesthesia in pa-tients undergoing facial plastic surgery can effectively improve the analgesic and sedative effects, and has a positive effect on shortening the postoperative recovery time and consciousness time of patients. At the same time, it is beneficial to reduce the incidence of adverse reactions, and the application safety is high.