To analyze the clinical efficacy of fumigation solution and sodium hyaluronate eye drops in the treatment of xerophthalmia. Methods From December 2021 to December 2022, 70 patients with xerophthalmia admitted to the Department of Ophthalmology, Ningxia Hospital of Traditional Chinese Medicine and Institute of Traditional Chinese Medicine were selected as the research objects. They were divided into control group and observation group by random number table method, with 35 patients in each group. The control group was treated with sodium hyaluronate eye drops, and the observation group was treated with Mingmu fumigation liquid and sodium hyaluronate eye drops. The clinical efficacy, TCM syndrome score, tear secretion test, tear film rupture time and corneal fluorescence staining were compared between the two groups. Results The total effective rate of treatment in the observation group was 97.56%, which was higher than 78.57% in the control group, and the difference was statistically significant (P <0.05). After treatment, the scores of dry eye, black eye nebula, white eye dryness and dry mouth in the observation group were lower than those in the control group, and the differences were statistically significant (P <0.05). After treatment, SIt and BUT in the observation group were higher than those in the control group, and FL was lower than that in the control group, the differences were statistically significant (P <0.05). Conclusion On the basis of sodium hyaluronate eye drops, Mingmu fumigation liquid is effective in the treatment of xerophthalmia with Qi and Yin deficiency syndrome. It is helpful to improve tear secretion, tear film rupture time and corneal fluorescence staining, reduce clinical symptoms, and has high safety.