To analyze the application value of psychological intervention in nursing care of female patients undergoing vulvar plastic surgery. Methods A total of 60 female patients who underwent vulva plastic surgery in our hospital from May 2021 to November 2022 were randomly divided into reference group and study group, with 32 cases in each group. The reference group was given routine nursing, and the study group was given psychological intervention on the basis of the reference group. The psychological status, sexual function, self-esteem and nursing satisfaction of the two groups were compared. Results The SAS score and SDS score of the two groups after nursing were lower than those before nursing, and the study group was lower than the reference group (P <0.05). The FSFI score and SES score of the two groups were higher than those before nursing, and the study group was higher than the reference group (P <0.05). The self-esteem score of the two groups was higher than those before nursing, and that in the study group was higher than that in the reference group (P <0.05). The nursing satisfaction of the study group was 100.00%, which was higher than 84.38% of the reference group (P <0.05). Conclusion The integration of psychological intervention into the nursing of female patients undergoing vulvar plastic surgery can effectively regulate the psychological state of patients, alleviate their negative emotions, enhance the patient's cooperation with the operation, improve the patient's sexual function, restore the patient's confidence in life, make the patient recognize the nursing work and improve the nursing satisfaction, which is worthy of application.