Polydeoxyribonucleotide (PDRN) is a mixture of specific DNA fragments that are extracted and purified primarily from the sperm cells of salmon. PDRN has various biological activities， such as anti-inflammation, tissue repair, wound healing promotion, angiogenesis stimulation, anti-melanin and anti-aging, etc. It has been widely studied in the field of skin. This article reviews the research progress of PDRN in skin, aiming to provide scientific reference for the development and utilization of PDRN.