To explore the effect of comprehensive nursing intervention on elderly patients with eczema. Methods A total of 76 elderly patients with eczema admitted to Jiufeng Street Community Health Service Center of East Lake New Technology Development Zone in Wuhan City, Hubei Province from April 2022 to April 2023 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 38 patients in each group. The control group was given routine nursing, and the observation group was given comprehensive nursing intervention. The symptom scores, nursing compliance and quality of life were compared between the two groups. Results The scores of pruritus, chapped degree, erythema, skin keratosis and skin lesion area in the two groups after nursing were lower than those before nursing, and those in the observation group were lower than those in the control group (P<0.05). The proportion of taking medicine on time, scientific diet, emotional control and cooperation treatment in the observation group was higher than that in the control group (P<0.05). The scores of physical function, role function, emotional function, social function and cognitive function in the observation group were higher than those in the control group (P<0.05). Conclusion The application of comprehensive nursing intervention in elderly patients with eczema is effective, which can improve the compliance of patients, effectively alleviate or eliminate their itching symptoms, and has positive significance for improving the quality of life of patients.