To investigate the effect of negative pressure wound therapy combined with continuous irrigation of recombinant human basic fibroblast growth factor in the treatment of chronic wounds. Methods A total of 62 patients with chronic wounds admitted to our hospital from November 2022 to November 2023 were randomly divided into control group and observation group, with 31 patients in each group. The control group was treated with negative pressure wound therapy combined with normal saline, and the observation group was treated with negative pressure wound therapy combined with Continuous Irrigation of recombinant human basic fibroblast growth factor. The pain degree, white blood cell count, C-reactive protein, granulation tissue coverage rate and wound healing rate were compared between the two groups. Results The VAS score, white blood cell count and C-reactive protein level in the observation group were better than those in the control group (P <0.05). The coverage rate of granulation tissue and wound healing rate in the observation group were higher than those in the control group (P <0.05). Conclusion Negative pressure wound therapy combined with continuous irrigation of recombinant human basic fibroblast growth factor can reduce wound infection rate, promote the regeneration of granulation tissue in the first stage, and reduce the interval time of the second stage operation. The clinical application value is definite.