To analyze the effect of topical human epidermal growth factor combined with erythromycin eye ointment in wound recovery after laser surgery. Methods A total of 64 patients who underwent laser freckle and nevus removal in our hospital from August 2021 to August 2023 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 32 patients in each group. The control group was treated with erythromycin eye ointment, and the observation group was treated with topical human epidermal growth factor combined with erythromycin eye ointment. The clinical efficacy, wound recovery index and satisfaction of the two groups were compared. Results The total effective rate of treatment in the observation group was 96.88%, which was higher than 78.13% in the control group (P <0.05). The wound healing time, scab formation time and scab shedding time in the observation group were shorter than those in the control group (P <0.05). The satisfaction of the observation group was 96.88%, which was higher than 75.00% of the control group (P <0.05). Conclusion The application of erythromycin eye ointment combined with topical human epidermal growth factor in the repair of wounds after laser surgery has a better effect, which can effectively shorten the wound healing time, accelerate postoperative recovery, and have higher patient satisfaction.