Objective To analyze the impact of high-quality nursing interventions on improving treatment compliance of patients with acupoint catgut embedding therapy. Methods From March 2022 to May 2023, 48 patients with acupoint catgut embedding therapy admitted in Zigong Fourth People's Hospital were selected as the research objects and randomly divided into control group and observation group, with 24 patients in each group. The control group was treated with routine nursing, and the observation group was treated with high quality nursing intervention. The treatment compliance, nursing efficiency, nursing satisfaction and mental health status of the two groups were compared. Results The total treatment compliance of the observation group was 100.00%, which was higher than 83.33% of the control group (P <0.05). The total effective rate of nursing in the observation group was 95.83%, which was higher than 75.00% in the control group (P <0.05). The total nursing satisfaction of the observation group was 95.83%, which was higher than 70.83% of the control group (P <0.05). The scores of SAS and SDS in the observation group were lower than those in the control group (P <0.05). Conclusion For patients with acupoint catgut embedding therapy, high quality nursing can improve patients' treatment compliance, nursing effect and nursing satisfaction, and improve their bad mood.