Chitosan from ganoderma lucidum is a positively charged natural polysaccharide with good biocompatibility, degradation, anti-inflammatory, antioxidant, antibacterial and wound healing promoting effects. Chitosan, as one of the effective ingredients in ganoderma lucidum, differs from chitosan in shrimp and crab shells in terms of physical and chemical properties, and has unique properties. At present, most of the commercialized chitosan comes from shrimp and crab shells, and there are relatively few chitosan products derived from Ganoder malucidum. This article reviews the characteristics of chitosan from ganoderma lucidum and its application prospects in the biomedical materials industry, in order to provide reference for the development and biomedical application of chitosan from ganoderma lucidum.