糠酸莫米松乳膏联合维A酸乳膏治疗黄褐斑的效果及安全性
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王媛(1983.2-),女,陕西西安人,本科,药师,主要从事药剂科相关工作

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魏兰兰(1991.2-),女,陕西宝鸡人,本科,药师,主要从事药剂科相关工作

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R758.4+2

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Efficacy and Safety of Mometasone Furoate Cream Combined with Tretinoin Cream in the Treatment of Chloasma
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    摘要:

    分析对黄褐斑患者采用糠酸莫米松乳膏联合维A酸乳膏治疗的效果及安全性。方法 选择空军 军医大学第二附属医院2022年1月-12月收治的70例黄褐斑患者为研究对象,随机分为对照组和观察组,每 组35例。对照组予以维A酸乳膏治疗,观察组予以糠酸莫米松乳膏联合维A酸乳膏治疗,比较两组症状积 分、临床疗效、生活质量及不良反应发生情况。结果 观察组治疗后症状积分低于对照组(P <0.05);观 察组治疗总有效率为94.29%,高于对照组的74.29%(P <0.05);观察组治疗后生活质量各项评分均高于 对照组(P <0.05);两组不良反应发生率比较,差异无统计学意义(P >0.05)。结论 维A酸乳膏联合糠 酸莫米松乳膏治疗黄褐斑的效果良好,可改善患者的临床症状,有利于提升其生活质量,同时联合应用的 安全性较高,不会增加不良反应发生风险。

    Abstract:

    To analyze the efficacy and safety of the combination of mometasone furoate cream and tretinoin cream in the treatment of chloasma. Methods A total of 70 patients with chloasma admitted to the Second Affiliated Hospital of Air Force Medical University from January to December 2022 were randomly divided into control group and observation group, with 35 patients in each group. The control group was treated with vitamin A acid cream, and the observation group was treated with mometasone furoate cream combined with tretinoin cream. The symptom scores, clinical efficacy, quality of life and adverse reactions were compared between the two groups. Results After treatment, the symptom score of the observation group was lower than that of the control group (P <0.05). The total effective rate of treatment in the observation group was 94.29%, which was higher than 74.29% in the control group (P <0.05). After treatment, the scores of quality of life in the observation group were higher than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P >0.05). Conclusion The combination of tretinoin cream and mometasone furoate cream has a good effect in the treatment of chloasma, which can improve their clinical symptoms and quality of life. At the same time, the combined application has high safety and will not increase the risk of adverse reactions.

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王媛,魏兰兰.糠酸莫米松乳膏联合维A酸乳膏治疗黄褐斑的效果及安全性[J].医学美学美容,2024,33(5):17-20.

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  • 在线发布日期: 2024-03-27
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