A型肉毒毒素注射联合透明质酸填充术治疗眉间纹的临床效果
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赵金华(1984.6-),女,河北沧州人,硕士,主治医师,主要从事整形美容方面研究

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R622


Clinical Effect of Type A Botulinum Toxin Injection Combined with Hyaluronic Acid Filling in the Treatment of Glabellar Frown Lines
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    摘要:

    探讨对眉间纹患者应用A型肉毒毒素注射联合透明质酸填充术治疗的效果。方法 选取 2022年10月-2023年6月青县人民医院收治的120例眉间纹患者为研究对象,根据随机数字表法分为对照 组和观察组,每组60例。对照组采用A型肉毒毒素注射治疗,观察组采用A型肉毒毒素注射联合透明质 酸填充术治疗,比较两组临床疗效、皱纹情况及复发情况。结果 观察组治疗总有效率为96.67%,高 于对照组的73.33%,差异有统计学意义(P <0.05);两组术后皱纹评分均低于术前,且观察组低于对 照组,差异有统计学意义(P <0.05);观察组复发率为3.33%,低于对照组的16.67%,差异有统计学 意义(P <0.05)。结论 对眉间纹患者予以A型肉毒毒素注射联合透明质酸填充术治疗的效果良好,可 有效淡化皱纹,且治疗后复发率较低,值得临床应用。

    Abstract:

    To investigate the effect of type A botulinum toxin injection combined with hyaluronic acid filling in patients with glabellar frown lines. Methods A total of 120 patients with labellar frown lines admitted to Qing County People's Hospital from October 2022 to June 2023 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 60 patients in each group. The control group was treated with type A botulinum toxin injection, and the observation group was treated with type A botulinum toxin injection combined with hyaluronic acid filling. The clinical efficacy, wrinkles and recurrence were compared between the two groups. Results The total effective rate of treatment in the observation group was 96.67%, which was higher than 73.33% in the control group, and the difference was statistically significant (P <0.05). The postoperative wrinkle scores of the two groups were lower than those before the operation, and the observation group was lower than the control group, and the difference was statistically significant (P <0.05). The recurrence rate of the observation group was 3.33%, which was lower than 16.67% of the control group, and the difference was statistically significant (P <0.05). Conclusion Type A botulinum toxin injection combined with hyaluronic acid filling is effective in the treatment of patients with glabellar frown lines, which can effectively dilute wrinkles and has a low recurrence rate. It is worthy of clinical application.

    参考文献
    [1]师茸,薛琨,杜宝林. A型肉毒毒素联合透明质酸注射治 疗中重度川字纹效果观察[J].中国美容整形外科杂 志,2021,32(6):375-376.
    [2]张伟,祝联.自体脂肪移植联合A型肉毒毒素注射治疗重 度眉间纹[J].组织工程与重建外科杂志,2021,17(5):413- 416.
    [3]刘杨.透明质酸填充术联合保妥适注射治疗眉间纹的疗 效与安全性分析[J].中国现代药物应用,2018,12(6):111- 113.
    [4]仲元奎,梁方,崔璐,等.A型肉毒毒素联合透明质酸钠微整 形注射在重塑颜面部轮廓中的效果评价[J].中国美容医 学,2021,30(12):26-30.
    [5]徐爽,高亮,李俊岑,等.A型肉毒毒素联合眉下切口矫治上 睑松弛和鱼尾纹[J].中国美容医学,2020,29(1):1-4.
    [6]郑文鸽,秦雪梅,高丽,等.衰老相关分泌表型的作用机制及 相关药物研究进展[J].药学学报,2020,55(1):8-14. [ 7 ]何梅,李晓庆,康道现,等.注射用透明质酸钠复合液 治疗眶周静态皱纹疗效观察[J].中国皮肤性病学杂 志,2020,34(2):229-232. [8]Kaufman-Janette J,Cox SE,Dayan S,et al.Botulinum Toxin Type A for Glabellar Frown Lines:What Impact of Higher Doses on Outcomes?[J].Toxins (Basel),2021,13(7):494. [9]Yoelin SG,Dhawan SS,Vitarella D,et al.Safety and Efficacy of EB-001,a Novel Type E Botulinum Toxin,in Subjects with Glabellar Frown Lines:Results of a Phase 2,Randomized,Placebo-Controlled,Ascending-Dose Study[J].Plast Reconstr Surg,2018,142(6):847e-855e. [10]李艳,艾红梅,梁伟中,等.微创针吸式皱眉肌切除并回填治 疗中重度眉间纹[J].中国医学科学院学报,2019,41(6):821- 824. [11]Yi KH,Lee JH,Hu HW,et al.Anatomical Proposal for Botulinum Neurotoxin Injection for Glabellar Frown Lines[J].Toxins (Basel),2022,14(4):268. [12]万道红,张璇.A型肉毒毒素联合透明质酸在鱼尾纹中的 治疗效果[J].医学美学美容,2021,30(6):64-65. [13]Güven? U,Ten B,Kaya T?,et al.Evaluation of supratrochlear artery depth and course variations by Doppler ultrasonography along the glabellar frown lines for safer filler injections[J].J Cosmet Dermatol,2022,21(12):6717-6726. [14]Song S,Lee YH,Hong JP,et al.Safety,efficacy,and onset of a novel botulinum toxin type A (Nabota) for the treatment of glabellar frown lines:a single-arm, prospective,phase 4 clinical study[J].Arch Craniofac Surg,2018,19(3):168-174. [15]沈婷,姚慧萍,杨子建,等.A型肉毒毒素注射治疗上 面部动态皱纹的疗效观察[J].中国美容整形外科杂 志,2021,32(2):80-83. [16]李峰,郑晓枫,乔菊,等.A型肉毒毒素注射治疗眉间纹的 高频超声研究[J].中华皮肤科杂志,2020,53(3):223-225. [ 1 7 ]卞媛媛,杨昕,陈若然,等. P P D O线联合A型肉毒素 治疗中重度眉间纹临床效果观察[ J ] . 临床军医杂 志,2020,48(1):83,86. [18]Li X,Sui C,Xia X,et al.Efficacy and Safety of Botulinum Toxin Type A for Treatment of Glabellar Lines:A Network Meta-Analysis of Randomized Controlled Trials[J]. Aesthetic Plast Surg,2023,47(1):365-377. [19]高明菊,杨名,吴炳为,等.A型肉毒毒素联合透明质酸治 疗眉间纹效果探讨[J].中国美容医学,2020,29(11):51-53. [20]王忠杰,张玫,王志军.联合应用A型肉毒毒素与软组织 填充剂治疗眉间纹的临床观察[J].中国美容整形外科杂 志,2011,22(11):656-658.
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赵金华. A型肉毒毒素注射联合透明质酸填充术治疗眉间纹的临床效果[J].医学美学美容,2024,33(5):42-45.

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  • 在线发布日期: 2024-03-27