To analyze the effect of pain nursing management on patients with orthopedic trauma skin grafting surgery. Methods From March 2020 to May 2021, 60 patients with orthopedic trauma skin grafting surgery in our hospital were selected as the research objects. They were divided into observation group and control group by random number table method, with 30 patients in each group. The control group was given routine nursing intervention, and the observation group was given pain nursing management intervention. The pain and nursing satisfaction of the two groups were compared. Results The pain score of the observation group were lower than those of the control group on the 2nd, 4th and 6th day after nursing (P <0.05). The satisfaction rate of the observation group was 93.33%, which was higher than 66.67% of the control group (P <0.05). Conclusion Compared with routine nursing intervention, the application effect of pain nursing management in the nursing of orthopedic trauma skin grafting surgery is good, which can effectively relieve the postoperative pain of patients, and the patients have higher satisfaction with nursing.