Objective To investigate the effect of Qingpeng ointment combined with loratadine and scraping in the treatment of damp-heat psoriasis. Methods A total of 84 patients with damp-heat psoriasis admitted to the Department of Dermatology of Jiangsu Provincial Hospital of Traditional Chinese Medicine from December 2022 to December 2023 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 42 patients in each group. The control group was treated with conventional oral loratadine combined with scraping therapy, and the observation group was treated with Qingpeng ointment on the basis of the control group. The severity of psoriasis, clinical efficacy quality of life and adverse reactions were compared between the two groups. Results After treatment, the PASI score of the observation group was lower than that of the control group (P <0.05). The total effective rate of treatment in the observation group was 90.48%, which was higher than 73.81% in the control group (P <0.05). The scores of DLQI in the observation group were lower than those in the control group (P <0.05). The incidence of adverse reactions in the observation group was 4.76%, which was lower than 19.04% in the control group (P <0.05). Conclusion Qingpeng ointment combined with loratadine and scraping has a satisfactory effect in the treatment of damp-heat psoriasis, which is helpful to improve the condition of psoriasis, improve the quality of life of patients, and has high safety.