Objective To analyze the effect of targeted nursing intervention combined with thunder fire moxibustion on the aesthetics of wound healing in patients undergoing gynecological tumor surgery. Methods A total of 100 patients who underwent gynecologic tumor surgery in our hospital from January to December 2023 were selected as the study subjects, and were divided into control group and observation group by random number table method, with 50 patients in each group. The control group was given general nursing, and the observation group was given targeted nursing intervention combined with thunder fire moxibustion. The aesthetics of wound healing and postoperative gastrointestinal function were compared between the two groups. Results The aesthetics rate of wound healing in the observation group was higher than that in the control group, and the difference was statistically significant (P <0.05). The incidence of postoperative abdominal distension in the observation group was lower than that in the control group, the anal exhaust time and the first defecation time were shorter than those in the control group, and the differences were statistically significant (P <0.05). Conclusion For patients with gynecological tumor surgery, targeted nursing intervention combined with thunder fire moxibustion can promote the improvement of aesthetics of postoperative incision healing, and improve the gastrointestinal function of patients.